A Brønsted or Lewis acid mediated semi-pinacolic rearrangement effected on the diastereomers
of cyclobutanol derivatives leads efficiently to useful intermediates in the synthesis
of cuparene-type sesquiterpenes. The cyclobutanols are themselves easily obtainable
from cyclopropyl phenyl sulfide.
antifugal agents - aldol reactions - rearrangements - ring expansion - ketones
